The largest damagers for cardiovascular disease are poor diet and smoking. On the other hand, different individuals are more vulnerable to heart disease on the basis of very small differences in their genes, dubbed as variants. While there have been many researches that have connected variants to cardiovascular dangers, it is not clear whether these variants have operational consequences, like modified protein or gene expression.
In a new research at Thomas Jefferson University from the Cardeza Foundation for Hematologic Research, scientists have found 2 slight gene versions that might modulate the platelet cells’ behavior, and subsequently impact the danger of getting cardiovascular disease.
Usually, when platelets are activated, they attach together and coagulate wounds to prevent bleeding. Platelets in disease can aggregate in response to triggers and add up to formation of plaque in diseases such as atherosclerosis. “Platelet volume and numbers are managed by the expression of specific genes,” claims Leonard Edelstein, senior author of the study. “If there is more of that gene, there are extra platelets and a propensity to clot more.”
CD36 is one such gene that manages platelet activation and levels. In the study posted in PLOS Genetics, the scientists, searched for small alterations in CD36’s genetic code. The review of info detected 81 alterations in the genome, two of which were operational variants, indicating they impacted expression of CD36.
On a related note, microbes are well-recognized amongst biologists as master engineers of helpful tiny molecules. When scientists at the University of Illinois looked closely at how a recognized microbe makes an identified supposed natural product, they were encountered with the finding of an entirely unidentified biochemical trick.
William Arends spearheaded the study with Elizabeth Parkinson (then-postdoctoral researcher). Parkinson is now chemistry’s assistant professor at Purdue University. Parkinson, Metcalf, and coauthors showed their work, which was backed by NIH, in Nature Chemical Biology.